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血清皮质醇水平作为驼压力标志物:与免疫学概况的关系
Jamal Hussen1, Hind Althagafi2
1Department of Microbiology, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.
Frontiers in veterinary science
|April 9, 2025
概括
血清皮质醇水平可靠地表明驼的压力,受性别和健康状况的影响. 皮质醇升高与免疫变化相关,突出其在驼生理学中的作用.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 动物生理学 动物生理学
- 免疫学 免疫学 免疫学
背景情况:
- 血清皮质醇是许多物种的关键压力指标.
- 了解驼的压力生理学对于动物福利和健康管理至关重要.
- 关于影响皮质醇的因素及其对驼免疫影响的数据有限.
研究的目的:
- 为了评估血清皮质醇水平作为驼 (Camelus dromedarius) 的压力标志物.
- 分析生理和病理因素对皮质醇水平的影响.
- 研究皮质醇水平与免疫学参数之间的关系.
主要方法:
- 血清皮质醇水平在四个组的169只驼中被测量:健康,屠宰前,Surra受影响和metritis受影响.
- 分析了免疫学参数,包括白细胞计数和T细胞种群.
- 使用流式细胞计量来评估细胞表面标记物表达 (CD4,γδ T 细胞,CD172a,CD14,CD163,CD45,MHC I).
- 测量了细胞中反应性氧物种 (ROS) 的产生.
主要成果:
- 女驼和非怀孕/哺乳期的雌驼的皮质醇水平高于雄驼和怀孕/非哺乳期的雌驼.
- 在压力 (屠宰前) 和患病的驼 (Surra,metritis) 中观察到皮质醇升高.
- 较高的皮质醇水平与白细胞症,中性恋,中性粒细胞与淋巴细胞比率的增加以及免疫细胞表型和功能的改变相关,包括增加ROS生产.
结论:
- 血清皮质醇是驼中可靠的压力指标.
- 性别和生殖状况显著影响皮质醇水平.
- 皮质醇调节驼的免疫系统,影响细胞和功能参数.
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