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在肝细胞癌中评估PDZD11:与AFP结合的预后价值和诊断潜力

Yiyun Ni¹, Bin Liu¹, Weizhen Zhang¹

¹The Central Hospital of Yongzhou, Yongzhou Clinical College, University of South China, Yongzhou, Hunan, China.

Frontiers in oncology

|April 9, 2025

概括

PDZ域蛋白11 (PDZD11) 在肝细胞癌 (HCC) 组织和血清中表达更高,预测预后不佳. PDZD11是HCC诊断和预后的有前途的生物标志物,特别是与AFP结合使用时.

科学领域:

在瘤学瘤学.
生物标志物发现发现
分子诊断学分子诊断

背景情况:

肝细胞癌 (HCC) 是一个重大的全球健康挑战,生存率很低.
早期诊断和预后标记对于改善HCC患者的治疗结果至关重要.
PDZ域蛋白11 (PDZD11) 在HCC病原和进展中的作用仍然在很大程度上未被探索.

研究的目的:

研究PDZD11作为HCC的潜在诊断和预后生物标志物.
评估HCC患者血清PDZD11水平的临床效用.
评估PDZD11与已确定的瘤标志物的联合诊断性能.

主要方法:

对TCGA和ICGC数据集的生物信息分析,以评估HCC中的PDZD11mRNA表达.
在HCC患者和健康对照组中对血清PDZD11水平的ELISA分析.
对PDZD11表达与整体存活率和临床病理因素的相关性分析.

主要成果:

在HCC组织中,PDZD11mRNA表达显著升高,与较低的整体存活率相关.
多变量分析确定PDZD11是HCC的独立预后因素.
在HCC患者中,血清PDZD11水平显著更高,随着疾病阶段和较差的表现状况而增加.
结合PDZD11和AFP显示了高的诊断准确性 (AUC=0.958).

结论:

PDZD11是HCC的一个有前途的预后生物标志物,在预测预后方面表现优于AFP.
血清PDZD11是HCC诊断的宝贵补充生物标志物,特别是在与AFP结合使用时.

关键词:

美国法新社 (AFP) 报道.在PDZD11中使用.肝细胞癌是肝细胞癌.预后预后预后血清学生物标志物血清学生物标志物

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