精选的晶体和体溶液对旋转血栓形成仪和血小板功能分析仪评估的凝血状态的影响:一种体外研究
Jakub Jonas1, Miroslav Durila1, Tomas Vymazal1
1Department of Anaesthesiology and Intensive Care Medicine, University Hospital in Motol, Prague, Czech Republic.
概括
血-莱特,阿尔布诺姆5%和格拉斯潘4%的溶液对血液凝结有不同的影响. 血-莱特对二次血静有极小的影响,而格拉斯潘4%显著降低了凝块强度和纤维素原水平. 所有的溶液都影响了原发性血小板功能.
科学领域:
- 麻醉学和重症监护医学
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 晶体和体溶液经常在重症监护和术后治疗中使用.
- 这些流体疗法可能会改变血液静止的微妙平衡.
- 了解常用解决方案的具体影响对于患者管理至关重要.
研究的目的:
- 评估Plasma-Lyte,albunorm 5%和Gelaspan 4%对初级和二级静血的体外影响.
- 为了比较这些常用的晶化物和合物溶液的静血作用.
- 为了确定哪种溶液对凝血参数产生最少的有害影响.
主要方法:
- 展望性体外研究涉及20名健康志愿者的血液样本.
- 使用旋转性血小板血栓测量 (ROTEM) 和血小板功能分析仪 (PFA).
- 与对照组相比,在用Plasma-Lyte,albunorm 5%或Gelaspan 4%稀释10%后评估血液静止.
主要成果:
- 血Lyte缩短了凝血时间 (EXTEM-CT) 和降低了纤维素原水平 (FIBTEM-MCF).
- 在多项测定中,Albunorm 5%和Gelaspan 4%延长了凝血时间 (EXTEM-CFT),降低了凝血的传播 (EXTEM-alpha) 和降低了凝血强度 (MCF).
- 在血小板功能测试中,所有溶液都延长了闭合时间,这表明初级血液静止受损.
结论:
- 在测试的溶液中,Plasma-Lyte对二次静血的影响最小.
- 在合物溶液中,Albunorm 5%对血液静止的影响最小.
- 格拉斯潘4%显著损害了凝血传播,强度和纤维素水平,而所有溶液都影响了原发性血小板功能.
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