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在服用阿皮克萨班的患者中,形术后的出血并发症
Sarah Van Dorin1, Andrei Schwartz1, Rosarie Tudas2
1Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, USA.
Cureus
|April 9, 2025
概括
像阿皮克萨班这样的直接口服抗凝剂会增加在宫过程中出血的风险. 高剂量,近期使用或同时使用抗凝剂显著增加了出血并发症的发生率.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肝炎和血栓塞在肝病中很常见.
- 腹腔腹术是一种用于排水的手术.
- 在接受像阿皮克萨班这样的直接口服抗凝剂 (DOAC) 的患者中,对形出血的风险尚不清楚.
研究的目的:
- 为了量化在服用阿皮克萨班的患者中进行体切除的重大出血的发生率.
- 为了确定与出血并发症相关的危险因素.
主要方法:
- 对于患者进行了回顾性队列研究,这些患者在染后7天内暴露于阿皮克萨班.
- 收集的数据包括出血并发症,阿皮克萨班剂量和时间以及患者的并发症.
- 这项研究于2016年1月至2022年4月在美国一家学术医院进行.
主要成果:
- 在91名患者中分析了365个体.
- 发生了20例出血 (5.5%),其中9例 (2.5%) 可能与手术有关.
- 致命出血发生在4名患者 (1.1%).
- 血出风险增加与每天两次服用10毫克的阿皮克萨班,同时服用抗凝剂,手术后6小时内服用阿皮克萨班和住院状态有关.
结论:
- 在接受阿皮克萨班治疗的患者中,空心术后的出血率高于历史估计.
- 暴露于阿皮克萨班,特别是高剂量,最近的使用,或与其他抗凝固剂结合,显著增加出血风险.
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