桑申圣配方通过增强突触的功能来阻碍阿尔茨海默病的认知功能和病理学
Shiquan Chang1, Nana Ding1, Yalin Li1
1Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese, Medicine, Jinan University, Guangzhou, China.
CNS neuroscience & therapeutics
|April 9, 2025
概括
桑申桑 (SSS) 通过改善认知功能和减少粉样质斑块,有效治疗阿尔茨海默病 (AD). 这种传统的中国草药配方增强了突触功能和神经递质平衡,用于多目标治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
背景情况:
- 阿尔茨海默病 (AD) 是一种神经退行性疾病,其特点是粉样β和病理,有效治疗方法有限.
- 目前的阿尔茨海默病疗法主要是症状性,突出显示了对新型治疗策略的需求.
研究的目的:
- 为了研究Sanshen San (SSS) 的治疗潜力,这是一个传统的中国草药配方,用于阿尔茨海默病 (AD).
- 在小鼠模型中评估SSS对认知功能和AD相关病理学的影响.
主要方法:
- 使用急性粉样蛋白-β (Aβ) 1-42注射和AD的5xFAD转基因小鼠模型.
- 使用行为测试评估认知功能 (Y迷宫,新型物体识别,莫里斯水迷宫).
- 通过RNA测序,代谢学,免疫光学,电子显微镜和西式涂抹来研究分子机制.
主要成果:
- 在AD小鼠模型中,SSS显著改善了认知表现,并减少了Aβ斑块负担.
- 该配方增强了微质细胞化,突触完整性,线粒体功能和自性.
- 转录组和代谢组分析显示,SSS恢复了突触传输和多巴胺类神经递质功能.
结论:
- 桑申圣 (SSS) 在缓解AD病理方面表现出显著的有效性.
- SSS通过多个目标起作用,包括增强突触功能,优化线粒体平衡,恢复神经递质平衡.
- SSS代表了阿尔茨海默病治疗的有前途的多目标治疗策略.
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