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Updated: May 15, 2025

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蛋白质-RNA对接基准v3.0 集成与结合亲缘关系

Shri Kant1, Chandran Nithin2, Sunandan Mukherjee3

  • 1Computational Structural Biology Laboratory, Department of Bioscience and Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur, India.

Proteins
|April 9, 2025
PubMed
概括

更新的蛋白质-RNA对接基准v3.0 (PRDBv3.0) 将蛋白质-RNA相互作用数据扩展到197个案例. 本资源有助于评估对接和绑定亲和力预测方法.

关键词:
结合性亲和力是一种结合性亲和力.形状的灵活性 形状的灵活性蛋白RNA复合体 蛋白RNA复合体蛋白质RNA对接方式蛋白RNA相互作用

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The Equilibrium Binding Constant and Binding Strength02:18

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Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
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Determining protein-drug binding can be achieved through indirect and direct methods, each providing valuable insights into the interaction between proteins and drugs.
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