一个药房居民驱动的虚拟药物基因组学诊所:利用人口仪表板管理工具来识别可能受益于测试的退伍军人
Lauren Jackson1, Emily Brandl1, Daniel Neu1
1Department of Pharmacy, Veterans Affairs Hospital, Memphis, TN, USA.
概括
人口仪表板工具确定了符合条件的退伍军人进行药物基因组学 (PGx) 测试. 一个由住院主导的诊所为大多数测试患者提供了PGx干预措施,增强了VA的精准医学.
科学领域:
- 药物基因组学 药物基因组学
- 精准医学是一门精准的医学.
- 医疗信息学 医疗信息学
背景情况:
- 退伍军人卫生管理局 (VHA) 旨在扩大退伍军人对药物基因组学 (PGx) 测试的准入.
- 人口仪表板工具 (PDT) 可以识别符合PGx测试条件的患者.
- 让药房居民参与PGx提高了他们的精准医学技能和患者护理效率.
研究的目的:
- 评估PDT在识别退伍军人进行PGx测试中的实用性.
- 评估居民驱动的虚拟PGx诊所在提供PGx护理方面的有效性.
- 确定PGx基因变异的类型和频率以及相关建议.
主要方法:
- 在VA医疗中心建立了一个虚拟PGx诊所,用于从2023年3月到2024年6月的门诊患者.
- 在VA PGx基因测试小组上,PGx PDT确定了VA PGx基因测试小组中新处方药的患者.
- 一个研究生2年级的药房住院医生,在教师监督下,管理诊所,获得同意,促进测试,并将结果和建议传达给提供者.
主要成果:
- 130名患者进行了查,其中104名 (80%的同意率) 接受了PGx测试.
- 鉴定了247个PGx基因变异,包括78个可操作的药物基因变异,18个用于遗传性疾病,17个用于转化.
- 向医疗服务提供者提出了90条建议,平均每名患者服用2.3种PGx影响的药物. 克洛皮多格雷尔,他类药物,塞特拉林和质子抑制剂的可操作变体是常见的.
结论:
- 人口仪表板工具有效地确定了符合药理基因组学测试条件的患者.
- 居民驱动的PGx诊所成功地为大多数被测试的患者进行了干预.
- 该模型展示了在VHA中扩大PGx服务的可行方法.
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