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Updated: May 15, 2025

Large-Scale Purification of Porcine or Bovine Photoreceptor Outer Segments for Phagocytosis Assays on Retinal Pigment Epithelial Cells
10:02

Large-Scale Purification of Porcine or Bovine Photoreceptor Outer Segments for Phagocytosis Assays on Retinal Pigment Epithelial Cells

Published on: December 12, 2014

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铁硫和铁响应元素结合蛋白质在Fuchs变症的角膜内皮细胞中介导铁的积累

Emma M Hartness1, Hanna Shevalye1,2, Jessica M Skeie1,2

  • 1University of Iowa Carver College of Medicine, Department of Ophthalmology and Visual Sciences, Iowa City, Iowa, United States.

Investigative ophthalmology & visual science
|April 9, 2025
PubMed
概括

福克斯内皮角膜缩症 (FECD) 涉及通过铁死 (ferroptosis) 导致的角膜内皮细胞 (CEC) 死亡,由铁的失调驱动. 这项研究揭示了FECD中铁-硫集群 (ISC) 和铁响应元素结合蛋白 (IREBP) 途径的改变,这表明铁积累和铁亡的新机制.

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In Vitro and In Vivo Models to Study Corneal Endothelial-mesenchymal Transition09:05

In Vitro and In Vivo Models to Study Corneal Endothelial-mesenchymal Transition

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