在免疫母亲的新生儿中对SARS-CoV-2进行短暂的中和活性
Marta Stracuzzi1, Claudia Vanetti2,3, Micaela Garziano3
1ASST Fatebenefratelli Sacco, Paediatric Infectious Disease Unit, Milan, Italy.
概括
母亲疫苗接种和混合免疫力为新生儿提供了对SARS-CoV-2的保护. 四个或更多的免疫事件显著提高中和活性,这表明强烈推怀孕促进剂量.
科学领域:
- 免疫学 免疫学 免疫学
- 新生儿健康 新生儿健康
- 病毒学 病毒学
背景情况:
- 6个月以下的新生儿因SARS-CoV-2引起的急性呼吸衰竭而面临住院的高风险.
- 新生儿的被动免疫对于预防病毒感染至关重要.
- 分析了母体疫苗接种和感染 (混合免疫) 对于它们在新生儿SARS-CoV-2保护中的作用.
研究的目的:
- 分析新生儿在怀孕期间被接种疫苗和/或感染的母亲被动获得的SARS-CoV-2的新生儿保护.
- 评估母体免疫事件对新生儿中和活性对SARS-CoV-2 Omicron变种的影响.
- 评估新生儿保护的持续时间和相关的细胞因子/化学因子概况.
主要方法:
- 接种疫苗的母亲的78名新生儿被录取.
- 婴儿根据母亲的SARS-CoV-2感染史 (接种疫苗与感染和接种疫苗) 进行了分层.
- 针对SARS-CoV-2的特定中和活性 (NA) 在出生,3个月和6个月时被测量;细胞因子/化学因子概况也被分析.
主要成果:
- 与仅接种疫苗的母亲相比,感染和接种疫苗的母亲的婴儿在出生时显示出更高的NA.
- 在分娩后3个月内,NA在两组中同样下降.
- 至少4次母体免疫事件显著增强新生儿NA,无论免疫类型或时间.
结论:
- 在怀孕期间对母亲进行疫苗接种对于新生儿在抗SARS-CoV-2的保护至关重要.
- 这项研究支持将怀孕助推剂量建议升级为"强烈推".
- 增强的母体免疫策略可以为新生儿提供至关重要的生命早期保护.
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