职业接触野生野火及其对系统性DNA损伤的影响
Filipa Esteves1, Joana Madureira2, Carla Costa2
1Environmental Health Department, National Institute of Health, Rua Alexandre Herculano, nº 321, 4000-055, Porto, Portugal; EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Rua das Taipas, n° 135, 4050-600, Porto, Portugal; Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR), Universidade do Porto, Rua das Taipas, n° 135, 4050-600, Porto, Portugal; Department of Public Health and Forensic Sciences, and Medical School, Faculty of Medicine, University of Porto, Rua Doutor Plácido da Costa, 4200-450, Porto, Portugal.
野火消防员在接触野火污染物后经历了DNA损伤的增加. 尿路标记物如2-化和与较高的DNA损伤相关,突出了职业风险.
科学领域:
- 环境健康 环境健康
- 职业医学 职业医学是专业的.
- 分子毒理学 分子毒理学
背景情况:
- 葡萄牙面临严重的野火,使消防员暴露在有害污染物中.
- 消防人员的职业暴露与疾病风险增加有关,包括癌症.
- 这些健康风险背后的生物机制需要进一步研究.
研究的目的:
- 评估野火现实事件后野火消防员早期影响生物标志物的变化.
- 调查暴露于污染物和遗传损伤之间的关系.
- 为改善消防员健康和安全提供机械数据.
主要方法:
- 一项涉及59名野地消防员的纵向研究.
- 收集了野火季节前后的血液和尿液样本.
- 评估了原发性DNA损伤,氧化性DNA损伤和DNA双链断裂 (γH2AX).
- 量化尿液中化多环芳代谢物 (OHPAH) 和金属化物.
主要成果:
- 在灭火后,原发性DNA损伤 (22%) 和氧化性DNA损伤 (23%) 显著增加.
- 尿中的2-氧化与增加氧化DNA损伤风险相关.
- 尿路与增加的初级和氧化DNA损伤有关.
- 暴露时间和呼吸困难与较高的初级DNA损伤有关.
结论:
- 野外灭火暴露会诱导消防员的遗传和分子变化.
- 研究结果提供了对职业健康风险的关键机制性见解.
- 结果支持对野地消防员实施加强的健康和安全措施.
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