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基于蒙特卡洛模拟的风险评估,对人类暴露在Platycladi精液中的多种真菌毒素

Ling Fang¹, Xiaokang Liu², Lin Feng²

¹State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, PR China; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, PR China.

Journal of chromatography. A

|April 9, 2025

概括

几乎所有Platycladi精液样本 (98.95%) 含有菌毒素,构成公共卫生风险. 在Platycladi精液中,阿弗拉托克辛和斯特里格马托西斯对健康构成重大威胁,需要监管监测.

科学领域:

食品科学食品科学食品科学
分析化学分析化学
毒理学毒理学毒理学

背景情况:

在Platycladi精液中的菌毒素污染是一个全球性的健康问题.
普拉蒂克拉迪精液被广泛消费,增加了暴露风险.
现有的检测方法可能不涵盖多种真菌毒素的概况.

研究的目的:

建立一种可靠的方法来检测Platycladi精液中的多种真菌毒素.
评估中国白银种子中真菌毒素的流行率和水平.
评估与从Platycladi精液消费中暴露的真菌毒素相关的人类健康风险.

主要方法:

开发了一种修改后的QuEChERS (快速,轻松,便宜,有效,坚固,安全) 提取技术.
采用超高性能液体染色学与并联质谱学 (UPLC-MS/MS) 进行敏感检测.
采用蒙特卡洛模拟来进行概率风险评估 (暴露幅度和危险系数).

主要成果:

在190个 (98.95%) 的Platycladi精液样本中,有188个被一种或多种真菌毒素污染.
替代醇单甲基乙烯 (92.63%),富莫尼辛B2 (91.58%),和胆固醇 (87.89%) 是最常见的.
在26个样本和18个样本中,甲毒素B1和总甲毒素分别超过了监管限制.

结论:

由于高密毒素污染,特别是亚毒素和硬质囊素,Platycladi精液对健康构成重大风险.
开发的UPLC-MS/MS方法为监管监测提供了一个强大的平台.
消费者健康保护需要严格控制Platycladi精液中的真菌毒素含量.

关键词:

人类暴露风险评估人类暴露风险评估蒙特卡洛模拟的蒙特卡洛模拟多种菌毒素多种菌毒素普拉提克拉迪的精液是什么在 UPLC-MS/MS 中使用.

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