功能障碍的条形形连接与精神分裂症患者的暴力风险更高有关
Juntao Lu1, Ningzhi Gou2, Simei Zhang3
1Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
精神分裂症的暴力患者表现出大脑连接的改变,特别是在状状回路中. 这些神经差异与精神病症有关,而不是像妄想这样的精神病症状.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 精神分裂症 (SZ) 患者有更高的暴力风险.
- 在SZ中暴力背后的神经机制仍然不清楚.
- 大脑异常可能与诸如妄想之类的精神病症状有关.
研究的目的:
- 检查SZ中暴力的神经相关性.
- 确定大脑异常是否与精神病症状有关.
- 研究精神分裂症中暴力的神经生物学.
主要方法:
- 140名男性 (18-50岁) 休息状态功能磁共振成像 (fMRI).
- 组包括暴力的SZ (VSZ),非暴力的SZ (NVSZ) 和健康的对照 (HC).
- 评估了临床症状和人格特征.
主要成果:
- 在VSZ组中,右侧胰岛 - 中侧额头和右侧状 (FFG) - 左侧尾状 (CAU) 的功能连接性 (FC) 增加.
- 在VSZ组中,右核合器 (NAcc) -FFG合器中显示出降低的FC.
- 在VSZ中,情感缺陷和NAcc-FFG FC之间的负相关性;与CAU-left中椎FC相关的怀疑性.
结论:
- 异常的皮层-子皮层连接,特别是条状-状电路,可能是SZ的暴力基础.
- 尾状 (CAU) 功能障碍可能与精神分裂症本身有关.
- 在SZ中,暴力与精神病特征有关,而不是精神病症状.
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