Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Protein-protein Interfaces02:04

Protein-protein Interfaces

12.4K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
12.4K
Ligand Binding Sites02:40

Ligand Binding Sites

12.6K
Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
12.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Pseudocapsule status combined with pathological parameters predicts prognosis in renal cell carcinoma.

Frontiers in oncology·2026
Same author

CMA-Nano: A DNA Methylation Detection Method for Nanopore Sequencing Data Based on a Cross-Modal Attention Mechanism.

ACS omega·2026
Same author

An Explainable Deep Learning Framework Integrating DNA Sequence and Transcription Initiation Signals for Gene Expression Prediction.

ACS synthetic biology·2026
Same author

Steroid Hormone Changes after Short-Term High-Dose Exposure to Cannabidiol in Healthy Subjects: An Exploratory Study.

Medical cannabis and cannabinoids·2026
Same author

LysePred: A Multiscale Convolutional Neural Network for Predicting Hemolytic Activity of Antimicrobial Peptides.

ACS synthetic biology·2026
Same author

MMTF-DTI: Drug-target interaction prediction via multimodal feature extraction and dynamic fusion.

Journal of biomedical informatics·2026

相关实验视频

Updated: May 15, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

951

PLM-IL4:通过蛋白质语言模型增强IL-4诱导的预测.

Ruiqi Liu1, Shankai Yan1, Zilong Zhang1

  • 1School of Computer Science and Technology, Hainan University, Haikou 570228, China.

Computational biology and chemistry
|April 9, 2025
PubMed
概括

这项研究增强了使用先进机器学习诱导的Interleukin-4 (IL-4) 的预测. 这种新的方法提高了潜在免疫疗法和疫苗开发的准确性.

关键词:
在 ENN ENN ENN 里面.在ESM-2模型中,诱导IL-4的可以诱导IL-4.蛋白质语言模型的模型在SMOTE中使用.

更多相关视频

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

68.4K
A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
07:59

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

14.9K

相关实验视频

Last Updated: May 15, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

951
A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

68.4K
A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
07:59

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

14.9K

科学领域:

  • 免疫学 免疫学 免疫学
  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学

背景情况:

  • 介素-4 (IL-4) 在免疫调节和过敏反应中起着至关重要的作用.
  • 预测IL-4诱导对于推进免疫治疗和疫苗开发至关重要.
  • 现有的预测方法面临着数据不平衡和特征提取的挑战.

研究的目的:

  • 为了提高IL-4诱导的预测准确度.
  • 为了解决类数据集中的数据不平衡问题.
  • 为了增强深度特征提取,以便更好地预测.

主要方法:

  • 使用SMOTE (合成少数人过量采样技术) 和ENN (编辑最近邻居) 来进行数据集平衡.
  • 采用30层ESM-2模型从序列中进行深度特征提取.
  • 应用了一个超参数调节的门式循环单元 (GRU) 模型进行分类.

主要成果:

  • 实现了0.98.98的曲线下的高面积 (AUC).
  • 达到了93.1%的预测准确度.
  • 在IL-4诱导预测方面显著改善.

结论:

  • 开发的方法为IL-4诱导提供了更高的预测准确度.
  • 这种方法对未来的免疫疗法和疫苗设计具有重大潜力.
  • PLM-IL4网络服务器和数据集是公开可用于研究的.