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在女性和家族腹腔大动脉动脉瘤患者中增加胸腔动脉瘤的风险

Heng Liu¹, Jorg L de Bruin², Arne S IJpma³

¹Department of Cardiology, Erasmus MC, Rotterdam, the Netherlands.

Journal of vascular surgery

|April 9, 2025

概括

女性腹腔大动脉动脉瘤 (AAA) 患者面临胸腔大动脉动脉瘤 (TAA) 风险的两倍. 家庭病史也会增加TAA的风险,而胸腔腹腔大动脉动脉瘤 (TAAA) 患者的存活率较低.

科学领域:

心血管医学心血管医学
遗传学遗传学是一个
放射学放射学是一门学科.

背景情况:

胸前动脉动脉瘤 (TAA) 在患有腹部动脉动脉瘤 (AAA) 的患者中比一般人群更为普遍.
在AAA患者中研究TAA发展的危险因素对于早期检测和管理至关重要.
了解性别,遗传和心血管风险因素的影响,可以完善风险分层.

研究的目的:

确定特定的腹腔大动脉动脉瘤 (AAA) 患者子组,这些患者患胸腔大动脉动脉瘤 (TAA) 或胸腔腹腔大动脉动脉瘤 (TAAA) 的风险更高.
为了确定性别,遗传倾向 (家族动脉瘤史或致病变体) 或常规心血管风险因素是否影响TAA风险.
评估胸腔动脉瘤对AAA患者5年生存期的影响.

主要方法:

从连续诊断的AAA患者的计算机断层扫描进行了回顾性分析.
评估多重大动脉动脉瘤的患病率,序列和位置.
对TAA风险的性别,家族动脉瘤史,基因变异和心血管风险因素 (年龄,吸烟,高血压,糖尿病,高胆固醇) 的统计分析.
评估AAA患者的5年存活率,有或没有胸腺动脉瘤.

主要成果:

最初,10.8%的AAA患者患有TAA;在随访期间,另外5.1%的患者患有TAA,2.4%的患者患有TAAA.
女性AAA患者的TAA风险增加了两倍,特别是在下降性大动脉.
具有家族动脉瘤史的AAA患者显示,TAA上升的风险增加了两倍.
与其他AAA患者组相比,女性胸腔腹腔大动脉动脉瘤 (TAAA) 患者的五年生存率较低.

结论:

在患有腹腔大动脉瘤 (AAA) 的患者中,女性性别和家族病史是发生胸腔大动脉瘤 (TAA) 的重要危险因素.
胸腔腹腔大动脉瘤 (TAAA) 诊断与生存率降低有关,特别是在女性患者中.
建议在AAA诊断后定期对上升和下降大动脉进行随访成像,以早期检测多重动脉瘤.

关键词:

腹腔大动脉动脉瘤腹腔大动脉动脉瘤动脉瘤基因是一种动脉瘤基因.动脉瘤遗传学动脉瘤遗传学大动脉动脉瘤后续研究研究家庭腹腔大动脉动脉瘤.幸存的生存方式胸前大动脉动脉瘤胸前大动脉动脉瘤胸腔腹腔大动脉动脉瘤是什么

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