种族和种族的差异,在统计剂的使用和眼睛高血压和开放角度玻璃眼的风险之间的关联
Abdelrahman M Elhusseiny1, Taher K Eleiwa2, Qais A Dihan3
1From the Department of Ophthalmology (A.M.E., Q.A.D., M.Z.C.), Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA; Department of Ophthalmology (A.M.E.), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
American journal of ophthalmology
|April 9, 2025
概括
在大多数种族群体,特别是非西班牙裔白人中,使用他类药物显著降低了眼睛高血压 (OHT) 和开角玻璃眼 (OAG) 的风险. 调查结果强调了这些协会中潜在的种族差异.
科学领域:
- 眼科医生 眼科 眼科
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 超脂血是心血管疾病的危险因素,可能影响眼部健康.
- 类药物被广泛用于治疗高脂血症,但它们对OHT和OAG等眼部疾病的影响在不同人群中尚不完全理解.
研究的目的:
- 调查他类药物使用与眼睛高血压 (OHT) 和开角玻璃眼 (OAG) 的发生率之间的关联.
- 检查这些跨不同种族和种族小组的关联,包括非西班牙裔白人,非西班牙裔非洲裔美国人,非西班牙裔亚洲人和西班牙裔.
主要方法:
- 使用TriNetX美国协作网络数据库进行回顾性队列研究.
- 包括40岁以上的超脂血症患者和至少4个他类药物处方.
- 在每个种族/种族队列中使用倾向分数匹配来控制混因素.
主要成果:
- 立方体使用与非西班牙裔白人1岁和5岁的OHT和OAG风险降低有关.
- 在非西班牙裔非洲裔美国人,西班牙裔和非西班牙裔亚洲人中观察到OAG风险降低5年.
- 在非西班牙裔非裔美国人中没有发现对OHT风险的显著影响,而在亚洲人和西班牙裔美国人中则稍后 (5年) 观察到影响.
结论:
- 在大多数研究的种族和族裔群体中,他类药物的使用显示出对OHT和OAG的保护性关联.
- 这些保护作用的时间和程度在不同人群中各不相同.
- 需要进一步的研究来阐明观察到的种族差异背后的机制.
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