早期引入食物和皮肤软化剂对花粉敏感性的影响:一个随机试验 (PreventADALL) 副研究
Sabina Wärnberg Gerdin1, Håvard O Skjerven2, Jon R Konradsen1
1Lung and Allergy Department for Children, Astrid Lindgren's Children's Hospital, Karolinska University Hospital, Stockholm, Sweden; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
概括
早期的食物引入没有影响花粉敏感化风险. 然而,婴儿的皮肤干预增加了树敏感度,这与早期皮肤屏障功能受损有关.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 皮肤病学 皮肤病学
- 儿科 儿科 儿科
背景情况:
- 花粉敏感性可能与常见食物过敏原中发现的蛋白质有关.
- 了解交叉反应性对于过敏预防策略至关重要.
研究的目的:
- 调查早期引入食物和皮肤软化剂是否可以防止树和草在3岁时引起敏感性.
- 要确定皮肤屏障功能是否介导这些影响,或者出生季节是否改变这些影响.
主要方法:
- 一个基于人口的随机对照试验,涉及2066名儿童.
- 干预措施包括早期引入食物 (常见过敏原的味道) 和皮肤软化剂 (油浴,奶油).
- 通过特定的IgE和皮肤刺伤测试来评估敏感性;调解分析使用跨皮肤水分流失.
主要成果:
- 早期的食物引入对花粉敏感性没有影响.
- 皮肤干预与树敏感性增加的风险相关 (OR 2.38,95% CI 1.43-3.95).
- 观察到皮肤干预对通过穿越皮肤流失水分的敏感性有显著的间接影响.
结论:
- 早期的饮食干预并不能防止花粉敏感化.
- 婴儿期皮肤屏障受损,可能被软化剂加剧,与树敏感性风险增加有关.
- 没有发现根据出生季节对影响的显著修改.
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