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在IIIA阶段皮肤黑色素瘤患者中辅助治疗的有效性

P Grover¹, S N Lo², I Li²

¹Melanoma Institute Australia, The University of Sydney, Sydney, Australia; Department of Medical Oncology, Fiona Stanley Hospital, Perth, Australia; Department of Medical Oncology, Sir Charles Gairdner Hospital, Perth, Australia.

Annals of oncology : official journal of the European Society for Medical Oncology

|April 9, 2025

概括

辅助向疗法 (TT) 对IIIA阶段黑色素瘤患者有前途,其表现优于抗编程细胞死亡蛋白1 (PD-1) 免疫疗法和单独观察. 需要进一步的研究,以在更大的研究中证实这些发现.

科学领域:

在瘤学瘤学.
皮肤病学皮肤病学
临床试验临床试验

背景情况:

在辅助治疗试验中,IIIA阶段黑色素瘤患者的代表性不足.
在这个群体中,辅助向治疗和免疫治疗的疗效尚不清楚.

研究的目的:

评估辅助抗编程细胞死亡蛋白1 (PD-1) 治疗,达布拉费尼布+特拉美丁尼布 (TT),以及在切除的IIIA阶段黑色素瘤中的观察 (OBS) 的有效性.
为了在治疗组之间比较无复发生存率 (RFS),无远程转移生存率 (DMFS) 和毒性率.

主要方法:

从34个中心对628名IIIA阶段黑色素瘤患者 (AJCC v8) 的回顾性分析.
患者接受了辅助抗PD-1,TT或OBS.
评估的结果包括RFS,DMFS和毒性率.

主要成果:

两年的RFS为抗PD-1的79.3%,TT的98.6%,OBS的84.3%.
两年的DMFS为抗PD-1的88.4%,TT的100%和OBS的91.1%.
较高的布雷斯洛厚度和线粒速率与复发风险增加相关.

结论:

与IIIA阶段黑色素瘤的观察相比,辅助抗PD-1治疗没有显著改善RFS或DMFS.
辅助性TT显示出有希望的结果,可能优于抗PD-1或OBS.
对于IIIA阶段的黑色素瘤辅助疗法,需要对更大的数据集和前性试验进行进一步的研究.

关键词:

没有远程转移的生存率.免疫疗法免疫疗法黑色素瘤是一种黑色素瘤.观察观察观察阶段IIIA 阶段IIIA

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