脂肪性肝病和相关亚型的全球高患病率:一个元分析
Glenn Jun Kit Ho1, Faith Xin Ning Tan1, N Apoorva Sasikumar1
1Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
概括
全球肥胖性肝病 (SLD) 影响37.5%的人口,在2型糖尿病或肥胖患者中患病率更高. 这凸显了迫切需要采取公共卫生干预措施来应对这种日益严重的健康问题.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 脂肪性肝病 (Steatotic liver disease,SLD) 是一个日益严重的全球性健康问题,存在多种形式.
- 目前缺乏对SLD患病率的全面了解.
- 这项研究解决了需要详细的全球流行数据的需求.
研究的目的:
- 为了估计脂肪性肝病 (SLD) 的全球患病率.
- 为了确定特定SLD亚型的流行率.
- 为了确定患有SLD患病率较高的人口子组.
主要方法:
- 对2023年1月至2024年8月期间发表的研究进行系统审查和元分析.
- 包括来自MEDLINE和EMBASE数据库的研究.
- 分析了44项涉及1100多万参与者的研究数据.
主要成果:
- 综合的SLD的全球流行率为37.5%.
- 亚型的患病率:与代谢功能障碍相关的脂肪性肝病 (33.6%),代谢性酒精相关的肝病 (4.1%) 和酒精相关的肝病 (2.2%).
- 在2型糖尿病患者 (70.2%) 和超重/肥胖人口 (70.7%) 中观察到患病率较高.
结论:
- 全球SLD的高流行率需要紧急的公共卫生干预措施.
- 针对可修改的风险因素是解决SLD负担的关键.
- 需要制定政策,以减轻全球SLD的影响.
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