患有直肠形的儿童患慢性病的风险增加
Esra Karabag Yilmaz1, Ali Ekber Hakalmaz2, Seha Saygılı1
1Department of Paediatric Nephrology, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
Journal of pediatric urology
|April 9, 2025
概括
患有直肠形 (ARM) 的儿童经常患有脏和尿路异常,增加他们患慢性脏病 (CKD) 的风险. 脏异常和膀功能障碍是这些患者中CKD发展的关键风险因素.
科学领域:
- 儿科泌尿外科 儿科泌尿外科
- 腎臟病學 (nephrology) 是一種醫學.
- 遗传异常是一种先天性异常.
背景情况:
- 阳道形 (ARM) 经常与泌尿病异常有关.
- 这些异常可能导致慢性病 (CKD) 的发展.
研究的目的:
- 为了确定ARM儿童中脏和尿路异常的患病率.
- 在这个队列中调查膀功能障碍的发生.
- 评估这些条件对CKD发展的影响.
主要方法:
- 对175名ARM儿童进行了回顾性分析.
- 根据翅膀传播和克里肯贝克标准对ARM进行分类.
- 临床,放射和血清肌素数据的评估.
- 根据KDIGO指南进行CKD诊断和分期.
主要成果:
- 48.5%的患者患有脏和/或尿路异常;32%患有膀功能障碍.
- 17%的患者患有CKD,主要是在2-4阶段.
- 脏异常 (p < 0.001) 和膀功能障碍 (p = 0.046) 独立地与CKD发展有关.
结论:
- 大约一半的ARM儿童表现出脏/尿路异常,三分之一患有膀功能障碍.
- 近五分之一的患者患有CKD,通常是在早期阶段.
- 脏异常和膀功能障碍是ARM儿童中CKD的重要危险因素,需要进行警监测.
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