生活方式和认知:根据LIBRA得分分区分平均生活方式和生活方式变化的影响
Kej Wesenhagen1, K Deckers2, Hsj Picavet1
1Centre for Prevention, Lifestyle and Health, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
The journal of prevention of Alzheimer's disease
|April 9, 2025
概括
较高的LIBRA评分与较差的认知功能有关,特别是在老年人中. 随着时间的推移,LIBRA得分的变化并不能始终预测认知能力下降.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 老年学是指老年学的学科.
背景情况:
- 脑健康生活方式 (LIBRA) 评分评估生活方式因素对大脑健康和痴呆风险的影响.
- 它包括可修改的因素,如酒精消费和风险因素,如高血压.
研究的目的:
- 研究LIBRA分数与认知功能之间的纵向关联.
- 确定这些关联是由于个人之间的差异,还是个人随着时间的推移而发生的变化.
主要方法:
- 分析了四个荷兰社区的队列 (n=13,657),包括Doetinchem队列研究,马斯特里赫特衰老研究,阿姆斯特丹长度衰老研究和鹿特丹研究.
- 混合混合模型被用来评估LIBRA平均分数和LIBRA分数变化与认知结果 (处理速度,记忆,口语流) 的关联.
- 模型根据年龄,性别,教育和学习效应进行了调整,并测试了与年龄的相互作用.
主要成果:
- 更高 (更不健康) 的LIBRA平均得分与更差的认知速度,记忆力和口语流性显著相关.
- 这些关联在老年人中更强烈,表明认知衰老加速,LIBRA分数更高.
- 在LIBRA得分中,人内变化没有显示出与认知衰退的一致关联.
结论:
- 一个人的平均LIBRA分数与认知功能长度相关,但随着时间的推移,分数的变化并不总是与认知衰退有关.
- 当前的LIBRA分数可能无法有效地捕捉生活方式的改善如何影响认知变化,作为一般人群中痴呆风险的代理.
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