亚thalamic神经元与后面的perisylvian皮质的尖峰相合预测了语音声音的准确性
Matteo Vissani1,2, Alan Bush3,4, Witold J Lipski5
1Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA. mvissani@mgh.harvard.edu.
Nature communications
|April 9, 2025
概括
这项研究揭示了下丘脑核 (STN) 神经元在发言过程中与皮质区域同步. 这种STN-皮质相互作用的延迟与语音声音错误相关,突出了其在发音中的作用.
科学领域:
- 神经科学是一个神经科学.
- 语音制作 语音制作
- 基底腺功能 基底腺功能
背景情况:
- 皮质 - 基底腺相互作用对人类行为至关重要,但直接的内记录是罕见的.
- 了解这些网络是解读语言等复杂认知功能的关键.
研究的目的:
- 为了研究人类大皮层和基底腺节在演讲过程中的同步活动.
- 探讨下丘脑核 (STN) 神经元活动在语音规划和产生中的作用.
主要方法:
- 在清醒的人类参与者中,从皮质的电皮质图 (ECoG) 和从基底质 (STN) 的单单元记录同步执行.
- 参与者在录音过程中重复音节,以捕捉与语音相关的神经活动.
主要成果:
- 个别的STN神经元表现出与多个皮层区域的短暂尖峰相合 (SPC).
- 在发言过程中,STN神经元尖峰的时间被相锁定为边缘上环和后部上环中的-α振荡.
- 延迟的STN-皮质相互作用与语音声音错误有关.
结论:
- 及时的STN-后皮质皮层相互作用对于听觉运动转换或语音工作记忆在语音规划中至关重要.
- 这些发现为研究其他人类行为中的基底 - 皮质相互作用提供了一个模型.
- 单独的射击速率模型不足以解释基底腺节电路的功能.
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