梅丽莎官员植物提取物对抗流感和新兴冠状病毒的抗病毒潜力
Tasneem Alsahafi1, Thamer Bouback2,3, Abdulaziz Albeshri1
1Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Scientific reports
|April 9, 2025
概括
梅丽莎花的提取物显示出对A型流感 (H1N1),SARS-CoV-2和MERS-CoV的强有力的抗病毒活性. 甲醇提取物表现出最高的疗效,表明其作为呼吸道病毒感染的天然治疗剂的潜力.
科学领域:
- 植物化学 植物化学
- 病毒学 病毒学
- 药理学 药理学是指药理学的学科.
背景情况:
- 梅丽莎 (Melissa officinalis) 是一种传统的药用草本,已有记录的生物活性.
- 人们越来越认识到M. officinalis提取物的抗病毒特性,需要对特定的病毒点进行详细的研究.
研究的目的:
- 评估各种M. officinalis提取物的体外抗病毒功效,以对抗甲型流感 (H1N1),SARS-CoV-2和MERS-CoV.
- 通过分子对接和GC-MS分析,识别对观察到的抗病毒活性负责的潜在生物活性化合物.
主要方法:
- 制备和测试水,乙,类,非类,乙醇和甲醇M. officinalis的提取物.
- 使用Vero E6和MDCK细胞系进行体外抗病毒检测以确定IC50和CC50值.
- 分子对接模拟和气色谱-质谱 (GC-MS) 用于化合物识别和结合亲和力分析.
主要成果:
- 水提取物显示出对SARS-CoV-2 (IC50 = 421.9μg/mL) 和MERS-CoV (IC50 = 222.1μg/mL) 的显著抑制.
- 甲醇提取物在所有测试病毒中表现出最高的抗病毒活性,具有较低的IC50值和高选择性指数 (SI) 对H1N1,SARS-CoV-2和MERS-CoV.
- 分子对接确定了诸如hesperidin和luteolin-7-glucoside-3'-glucuronide之类的化合物,它们与病毒尖端糖蛋白具有很高的结合亲和力,而GC-MS检测到了多可萨赫萨酸 (DHA) 和酸.
结论:
- M. officinalis 提取物,特别是甲醇提取物,对 H1N1,SARS-CoV-2 和 MERS-CoV.具有显著的广泛抗病毒活性.
- 在M. officinalis提取物中的生物活性化合物显示出抑制病毒进入和复制的潜力.
- 这些发现支持进一步发展M. officinalis作为抗病毒治疗呼吸道感染的天然来源.
关键词:
梅丽莎·奥菲西纳利斯 (Melissa officinalis) 是一个公务员.抗病毒药物是一种抗病毒药.细胞毒性 细胞毒性与药物相似的情况.流感 H1N1 流感 H1N1 是一种流感.人类的冠状病毒.这就是MERS-CoV.分子对接 分子对接植物化学物质 植物化学物质这就是SARS-CoV-2病毒.更多相关视频
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