了解栓塞运输和源到目的地,绘制由左心室辅助装置驱动的血液动力学中的血栓栓塞的映射
Sreeparna Majee1, Akshita Sahni1, Jay D Pal2
1Paul M Rady Department of Mechanical Engineering, University of Colorado Boulder, Boulder, USA.
Scientific reports
|April 9, 2025
概括
这项研究引入了一个计算模型来跟踪左心室辅助器件 (LVAD) 中的血栓. 该框架有助于了解凝块运动,这对于预防心力衰竭患者中风至关重要.
科学领域:
- 生物医学工程 生物医学工程
- 心血管科学 心血管科学
- 计算流体动力学的流体动力学.
背景情况:
- 左心室辅助器械 (LVAD) 对晚期心力衰竭至关重要,但会带来血栓栓塞并发症的风险,包括缺血性中风.
- 尽管设计和抗凝剂得到了改进,但血栓栓塞事件仍然是LVAD患者的一个重大问题.
研究的目的:
- 开发和验证一个定量 in silico 框架,以表征 LVAD 血液动力学中的血栓栓塞转移和分布.
- 通过标准的临床成像或数据无法获得的关于栓塞动态的洞察力.
主要方法:
- 使用计算框架进行了系统的数值实验,以模拟血栓栓塞运输.
- 该框架基于LVAD输出流的输送模式量化了移植瘤,脉冲调制,栓塞大小和来源.
- 栓塞分布模式与血液动力学描述符相关,如螺旋性,旋转性和壁剪应力.
主要成果:
- 在in silico框架下,在各种条件下,成功量化了血栓栓塞的源至目的地运输模式.
- 栓塞分布被证明偏离纯粹的血液动力学模式,受大小依赖的相互作用和喷气冲击的影响.
- 这项研究建立了对栓塞动态的宝贵见解,提供了比传统方法更深入的理解.
结论:
- 开发的计算框架为分析LVAD患者的血栓栓塞动态提供了强大的工具.
- 了解这些动态对于开发策略来减轻与LVAD治疗相关的中风风险至关重要.
- 这种in silico方法为改善LVAD安全性和患者结果提供了必要的新见解.
相关概念视频
01:30Venous Thrombosis I: Introduction
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
01:29Venous Thrombosis III: Interprofessional Care
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
01:29Pulmonary Embolism I: Introduction
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
01:29Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
01:29Hemorrhagic Stroke ll: Pathophysiology
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
01:19Pulmonary Embolism I: Introduction
A blood clot, or thrombus, is a semi-solid mass composed of fibrin, platelets, and red blood cells. When it forms within a vessel, it can obstruct blood flow, known as thrombosis. If part of the clot detaches, it becomes an embolus that can travel and block distant vessels. When this occurs in the pulmonary arteries, it causes a condition known as pulmonary embolism (PE).Origin and ImpactMost often, the embolus originates from a thrombus in the deep veins of the lower limbs, a condition called...