跨种族的孟德尔随机化分析揭示了空气污染和结石风险之间的因果关系
Shuangping Li1,2, Aijia Mu2, Zhinan Jing2
1Department of Urology, Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, China.
Scientific reports
|April 9, 2025
概括
暴露于空气污染的组成部分颗粒物2.5吸收度,显著增加了欧洲人口的结石风险. 控制空气污染可能有助于预防结石.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學.
- 遗传流行病学遗传流行病学
背景情况:
- 越来越多的证据将空气污染暴露与结石发病率的增加联系在一起.
- 以前的研究方法在确定因果关系方面存在局限性.
- 空气污染是一个重大的全球健康问题,需要进行因果调查.
研究的目的:
- 调查各种空气污染物与石风险之间的因果关系.
- 利用全基因组关联研究 (GWAS) 和门德尔随机化 (MR) 来进行强大的因果推断.
- 分析包括欧洲,东亚和南亚在内的不同人口的数据.
主要方法:
- 采用双样本和多变量门德尔随机化 (MR) 分析.
- 利用了来自英国生物银行,芬兰生物银行和日本生物银行的总结数据集.
- 应用了逆方差加权 (IVW),MR-Egger和加权中位数方法,以及灵敏度分析.
主要成果:
- 颗粒物2.5吸收率显示,在欧洲人中,与结石风险有统计学意义的相关性 (OR=1.40,P=0.04).
- 多变量MR证实了PM2.5吸收和结石风险增加之间的直接因果关系 (OR=1.77,P=0.03).
- 对于主要发现,没有发现显著的异质性,性或敏感性问题.
结论:
- 颗粒物2.5吸收率与欧洲人群中结石风险增加有关.
- 研究结果强调了空气污染,特别是PM2.5吸收对结石发展的潜在影响.
- 控制空气污染,特别是PM2.5,可能是预防结石的关键策略.
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