单细胞与HDL胆固醇比率 (MHR) 是一种新的痛风风险指标
Liangyu Mi1, Xiaoyao He2, Jinfang Gao1,3
1Shanxi Bethune Hospital, Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Scientific reports
|April 9, 2025
概括
单细胞与HDL-C比率 (MHR) 与美国成年人中痛风风险增加有关. 更高的MHR也与更严重的痛风相关,特别是在功能障碍患者中.
科学领域:
- 类风湿病学 类风湿病学
- 心血管健康 心血管健康
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 痛风是一种常见的炎症性关节炎,与单细胞升高和降低高密度脂蛋白胆固醇 (HDL-C) 相关.
- 单细胞与HDL-C比率 (MHR) 之前没有与痛风风险相关的研究.
研究的目的:
- 调查MHR与美国成年人中痛风风险之间的关联.
- 检查MHR在患有合并性功能障碍的痛风患者中的作用.
- 为痛风预防和治疗策略提供理论基础.
主要方法:
- 国家健康和营养检查调查 (NHANES) 数据 (2005-2016) 的横截面分析.
- 涉及7247名参与者,使用多重逻辑回归,子组分析和非线性关系探索.
- 评估了MHR水平和痛风患病率之间的相关性.
主要成果:
- 在痛风患者 (0.54 ± 0.31) 和非痛风患者 (0.47 ± 0.24) 中,MHR显著更高.
- 调整后的MHR显示与痛风风险有显著的关联 (OR = 1.6,P = 0.012).
- 在患有痛风的功能障碍患者中,MHR与痛风严重程度的增加密切相关 (OR = 7.4,P = 0.001).
结论:
- 在美国成年人中,MHR和痛风风险之间存在显著的正相关性.
- 在痛风患者中,MHR与功能障碍的严重程度有关.
- MHR可能是评估痛风风险及其并发症的有价值指标.
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