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Updated: May 15, 2025

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
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Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

Published on: September 14, 2018

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针对抗体对无处不在的有效载荷的位点定向的多价值结合

Angela F El Hebieshy1,2, Zacharias Wijfjes3,4, Camille M Le Gall3

  • 1Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands. a.f.el_hebieshy@lumc.nl.

Nature biomedical engineering
|April 9, 2025
PubMed
概括

一种新的ubi-tagging技术使有效的,位点定向的多价值抗体结合成为可能. 这种方法快速创建用于先进诊断和治疗的同质抗体结合体,包括双特异性T细胞参与者.

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Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates

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Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting11:58

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相关概念视频

Antibody Actions01:26

Antibody Actions

Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
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