衰老表型与慢性病之间的关联:来自NHANES和门德尔随机化的证据
Yukai Zhang1, Chenwei Zhang1, Peiyun He2
1The First Hospital of Shanxi Medical University, Taiyuan, 030000, Shanxi, China.
International urology and nephrology
|April 9, 2025
概括
像PhenoAge这样的生物衰老表型与慢性病 (CKD) 风险增加有关. 较短的端粒长度也因果上增加了CKD风险,这表明炎症调解是预防策略.
科学领域:
- 老年学是一门学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 遗传学 是一个遗传学.
背景情况:
- 生物衰老与各种疾病有关.
- 衰老表型与慢性病 (CKD) 患病率之间的关联需要进一步调查.
- 衰老的表型包括PhenoAge (PA),Klemera-Doubal方法 (KDM),全静电负荷 (AL),全静电失调 (HD) 和端粒长度 (TL).
研究的目的:
- 调查衰老表型对CKD患病率的影响.
- 检查衰老和CKD的临床相关性和遗传易感性方面.
- 探索端粒长度和CKD之间的因果关系.
主要方法:
- 从国家健康和营养检查调查 (2006-2015) 中对7482名参与者的分析.
- 逻辑回归和受限立方线 (RCS) 模型用于评估线性和非线性关联.
- 门德尔随机化分析以确定端粒长度和CKD之间的因果关系.
主要成果:
- PA,KDM,AL和HD与增加CKD患病率有关;PA仍然显著 (OR=1.0714).
- RCS曲线显示了PA,AL,HD和CKD之间的非线性关系 (P<0.001).
- 炎症标志物调解了这种关联;端粒长度因果上增加了CKD风险 (发现OR=0.892,复制OR=0.872).
结论:
- 衰老的表型与CKD风险密切相关.
- 炎症标志物调解了衰老和CKD之间的关系.
- 这些发现支持早期疾病预防和治疗脏病的治疗策略的制定.
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