卡尔西费迪奥尔和胆卡尔西费罗尔对绝经后妇女肌肉功能的影响:一项随机对照试验
Heike A Bischoff-Ferrari1,2,3, Bess Dawson-Hughes4, John E Orav5
1Department of Geriatrics and Aging Research, University of Zurich, Tièchestrasse 99, 8037, Zurich, Switzerland. Heikea.bischoff-ferrari@uzh.ch.
概括
二醇和高剂量维生素D3在患有骨质疏松症或骨质疏松症的绝经后妇女中没有改善下肢功能. 补充剂在改善步行速度或力量方面与安慰剂相比没有显著的益处.
科学领域:
- 内分泌学 在内分泌学.
- 老年学是一门学科.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 有限的证据表明,基醇对经绝经后患有骨质疏松症或骨质疏松症的女性下肢功能的疗效有限.
- 维生素D补充剂是常见的,但对于功能性结果的最佳形式和剂量仍在研究中.
研究的目的:
- 为了比较calcifediol,维生素D3和安慰剂对绝经后妇女下肢功能的影响.
- 为了评估20μg/天calcifediol与3200 IU/天维生素D3在改善功能方面的疗效.
主要方法:
- 一项三臂,双盲,随机对照试验 (RCT) 涉及152名年龄在50-70岁的绝经后妇女,患有骨质疏松症或骨质疏松症和维生素D缺乏症.
- 参与者每天接受20μg的calcifediol,3200 IU维生素D3或安慰剂6个月.
- 用步行速度,膝盖力量和重复的坐立测试来评估下肢功能.
主要成果:
- 在calcifediol,维生素D3和安慰剂组之间没有观察到下肢功能的显著差异.
- 在功能测试中的成功 (改善或维持) 的调整后的概率在所有三组中都是相似的.
- 基线特征和功能测试是平衡的,坚持度很高.
结论:
- 每日补充卡尔西费迪奥尔或高剂量维生素D3并不能支持 osteopenia/骨质疏松症和维生素D不足的更年轻的绝经后妇女下肢功能的改善.
- 研究结果不支持在这个人群中使用这些补充剂来增强或维持下肢功能.
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