膀癌的单细胞地图揭示了动态细胞组成和内皮细胞在进展过程中的功能转变
Hongjian Song1,2,3, Guixiang Xie4, Yaowei Li1,2,3
1NHC Key Laboratory of Molecular Probe and Targeted Theranostics, The Second Affiliated Hospital of Harbin Medical University, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, 150001, China.
Discover oncology
|April 9, 2025
概括
膀癌 (BC) 中的内皮细胞 (EC) 在非肌肉侵入性 (NMIBC) 和肌肉侵入性 (MIBC) 阶段表现出不同的功能. 在MIBC中特定的EC子集可能会驱动瘤的进展,这表明新的血管向疗法.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 生物信息学是一种生物信息学.
背景情况:
- 膀癌 (BC) 在非肌肉侵入性 (NMIBC) 和肌肉侵入性 (MIBC) 阶段之间表现出显著的异质性.
- 瘤微环境 (TME) 中的内皮细胞 (EC) 对血管生成和免疫调节至关重要,但它们在BC进展中的具体作用尚不清楚.
研究的目的:
- 用单细胞RNA测序来描述NMIBC与MIBC中的内皮细胞异质性和功能状态.
- 阐明在BC进展过程中涉及ECs的细胞-细胞通信网络.
主要方法:
- 对47名BC患者的公开单细胞RNA测序数据集的分析.
- 利用像CellChat这样的计算工具来重建细胞间的通信网络.
- 专注于与血管生成,免疫交叉和细胞外矩阵重塑相关的途径.
主要成果:
- 在NMIBC和MIBC中确定了EC的独特转录特征.
- NMIBC ECs使用HMGB1和CXCL12信号进行粘附和迁移.
- 在MIBC中,ADAM10+ EC子集与血管改造和Wnt信号 (CTNNB1) 相关.
结论:
- 在BC中展示了特定阶段的EC表型和信号网络.
- 突出了MIBC特定的ADAM10+ EC子集,可能导致瘤进展.
- 在BC中确定了适应阶段,针对血管的治疗机会.
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