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Updated: May 15, 2025

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可诱导促进体和无处不在的染色体开放元件 (UCOE) 之间的终结序列减少了基因表达泄漏和沉默

Tomoki Yanagi1, Shean Fu Phen1,2, Jonah Ayala1

  • 1Department of Biomedical Engineering, New York University (NYU) Tandon School of Engineering, Brooklyn, NY, USA.

Journal of biological engineering
|April 9, 2025
PubMed
概括

无处不在的染色体开放元素 (A2UCOE) 可以导致诱导系统中的基因泄漏. 添加SV40多A序列消除了这种泄漏,改善了iPSC应用的基因电路功能.

关键词:
基因沉默是一种基因沉默.基因组编辑 基因组编辑基因组工程是基因组工程.合成生物学 合成生物学转变差异化转变差异化

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