一项关于血清Klotho水平与美国糖尿病人群中全因死亡率之间的相关性队列研究
Kangxiang Wu1, Jiaqi Chen1, Yiying Lin1
1Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Diabetology & metabolic syndrome
|April 9, 2025
概括
低Klotho水平与糖尿病患者的较高死亡风险有关,年龄显著介导这种关联. 这突出了Klotho的特点.
科学领域:
- 老年学和内分泌学.
- 生物标志物和死亡风险
- 衰老和慢性疾病研究研究
背景情况:
- 全球糖尿病患病率正在上升,在管理其并发症方面取得的进展有限.
- 克洛托是一种抗衰老蛋白,可以减轻氧化应激和炎症.
- 之前的研究将克洛托与美国普通人口的全因死亡率联系起来.
研究的目的:
- 研究Klotho水平与全因死亡率之间的关联,特别是在糖尿病患者中.
- 探索非线性关系,并确定Klotho水平的潜在值.
- 确定年龄在克洛托-死亡率联系中的调解作用.
主要方法:
- 从国家健康和营养检查调查 (2007-2016) 中分析了3,560名个人.
- 使用了多变量Cox比例危险回归和受限制的立方线模型.
- 进行了调解分析,以评估年龄的作用.
主要成果:
- 在较低的Klotho水平和增加全因死亡率之间发现了显著的关联.
- 确定了一个非线性关系,临界值为829.138 pg/mL.
- 年龄是一个显著的调解因素,解释了克洛托和死亡率相关性的76.1%.
结论:
- 低Klotho水平 (<829.138 pg/mL) 与糖尿病全因死亡风险增加密切相关.
- 克洛托和糖尿病患者的死亡率之间的关系是非线性的,并且因年龄而显著介导.
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