Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Globular and Fibrous Proteins02:21

Globular and Fibrous Proteins

43.0K
Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
43.0K
Types of Intermediate Filaments01:31

Types of Intermediate Filaments

3.5K
The intermediate filaments are an essential component of the cytoskeleton. Presently six types of intermediate filament have been identified. Type I and II are acidic and basic keratin proteins. Type III is of mesodermal origin and comprises four proteins: vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Vimentin is commonly found in mesenchymal cells, desmin in muscle cells, GFAP in astrocytes, while peripherin is found in peripheral nervous system neurons (PNS). Type...
3.5K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

7.2K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
7.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Prognostic nutritional index at discharge as a practical bedside tool for long-term all-cause mortality risk in pneumonia-induced sepsis survivors.

Frontiers in nutrition·2026
Same author

Blockade of NKp46⁻ CCR6⁻ ILC3 autophagy protects against necrotizing enterocolitis by restoring energy metabolism balance in mice.

Nature communications·2026
Same author

Probiotic interventions maintain intestinal barrier function and alleviate necrotizing enterocolitis by inhibiting ferroptosis in intestinal PMN-MDSCs.

Cell death & disease·2026
Same author

Sodium alginate-green synthetic nano-silica/chitosan-thyme essential oil bilayer film for tomato preservation.

Food chemistry·2026
Same author

CD90 Promotes Gastric Cancer Progression by Regulating SLC1A5-Mediated Glutamine Metabolism Through YY1.

Cancer science·2026
Same author

A Deep Learning-Based Method for Non-Destructive Estimation of Carbonate Carbon Storage in Biogenic Shells on Marine Engineering Materials.

Materials (Basel, Switzerland)·2026

相关实验视频

Updated: May 15, 2025

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
09:34

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

6.6K

IGF2BP2:一个m6读者,影响细胞功能和疾病进展.

Siyi Liu1,2, Shan Liao3, Junyu He4

  • 1Department of Radiation Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University/Hunan Cancer Hospital, Changsha, 410013, Hunan, China.

Cellular & molecular biology letters
|April 9, 2025
PubMed
概括
此摘要是机器生成的。

胰岛素样生长因子2 mRNA结合蛋白2 (IGF2BP2) 通过N6 - 甲基氨酸 (m6A) 修改增强了目标基因mRNA的稳定性. 这调节了关键的细胞过程和疾病进展,提供了治疗潜力.

关键词:
血管新生的产生.细胞干性细胞干性皮质介质酶过渡 皮质介质过渡铁化是铁化的一种.在IGF2BP2BP2的基础上.

更多相关视频

Evaluation of Protein–Protein Interactions using an On-Membrane Digestion Technique
07:07

Evaluation of Protein–Protein Interactions using an On-Membrane Digestion Technique

Published on: July 19, 2019

6.5K
Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry
09:38

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry

Published on: June 26, 2019

7.9K

相关实验视频

Last Updated: May 15, 2025

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
09:34

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

6.6K
Evaluation of Protein–Protein Interactions using an On-Membrane Digestion Technique
07:07

Evaluation of Protein–Protein Interactions using an On-Membrane Digestion Technique

Published on: July 19, 2019

6.5K
Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry
09:38

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry

Published on: June 26, 2019

7.9K

科学领域:

  • 分子生物学分子生物学
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 癌症研究 癌症研究

背景情况:

  • 胰岛素样生长因子2 mRNA结合蛋白2 (IGF2BP2) 是N6 - 甲基氨酸 (m6A) 修饰的关键读者.
  • IGF2BP2识别并结合目标mRNA上的m6A位点,使它们稳定并影响基因表达.
  • 调节失调的IGF2BP2-介导的m6 一种修改与各种疾病有关.

研究的目的:

  • 通过m6A修改来提高mRNA稳定性的IGF2BP2的分子机制.
  • 阐明IGF2BP2在调节细胞铁亡,上皮 - 介质细胞过渡 (EMT),茎状,血管生成,炎症和脂质代谢中的作用.
  • 了解IGF2BP2对疾病进展的影响及其作为治疗点的潜力.

主要方法:

  • 文献综述侧重于分子机制.
  • 对研究IGF2BP2在细胞功能和疾病中的作用的分析.
  • 综合关于IGF2BP的当前研究进展2.2.

主要成果:

  • IGF2BP2通过m6A结合提高了下游目标的mRNA稳定性.
  • IGF2BP2显著影响铁,EMT,茎,血管生成,炎症反应和脂质代谢.
  • IGF2BP2的功能对疾病进展至关重要,特别是在瘤中.

结论:

  • IGF2BP2通过m6A-依赖的mRNA稳定,在调节基本细胞过程中发挥着至关重要的作用.
  • 了解IGF2BP2的机制为细胞功能,如铁和EMT提供了新的视角.
  • 向IGF2BP2为瘤和其他疾病提供了一个有前途的治疗策略.