gabapentinoid 处方趋势:一项全国性的丹麦药物使用研究
Anton Pottegård1, Lotte Rasmussen1, Morten Olesen1
1Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.
British journal of clinical pharmacology
|April 10, 2025
概括
丹麦的 gabapentinoid 处方量增加了近四倍,老年人使用率最高. 对 gabapentin 和 pregabalin 的长期坚持特别低,突出了对合理处方的担忧.
科学领域:
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- gabapentin 和pregabalin (gabapentinoids) 越来越多地用于各种疾病.
- 由于担心过度使用,滥用和滥用 gabapentinoids,需要详细的利用数据.
研究的目的:
- 提供关于2010年至2023年丹麦 gabapentinoid 用量的全面全国数据.
- 为这种药物类别提供合理的处方实践信息.
主要方法:
- 一项使用丹麦医疗保健登记册进行的全国性描述性药物使用研究.
- 分析整体使用模式,时间趋势,用户人口统计,治疗持续时间和同时使用药物的分析.
主要成果:
- gabapentinoid 的患病率增加了近四倍 (每 1000 名成年人中有 11 至 41 名),80 岁以上的个人使用率最高.
- 用户的中位数年龄增加,同时使用二类药物或阿片类药物下降.
- 连续3年治疗的坚持率很低 (7%),22%的患者在3年后接受治疗,包括休息时间;使用是倾斜的,1%的用户占总使用量的7.3%.
结论:
- gabapentinoid 的使用量急剧增加,特别是在老年人中.
- 较低的坚持表明需要更加关注对 gabapentinoids 的合理处方.
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