素通过准SIRT1来调节内质网膜压力,以改善小鼠DSS诱导的性结肠炎
Hai-Xiang Guo1, Zhong-Hao Ji1,2, Bing-Bing Wang1
1Department of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun, China.
概括
丁醇 (Lut) 通过减轻炎症,肠道屏障损伤和内分泌网膜 (ER) 压力,有效地降低了小鼠的性结肠炎 (UC) 症状. 这种天然的黄胺在预防人类炎症性疾病方面表现有前途.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病,发病率越来越高.
- 目前的治疗方法有局限性,需要新的治疗策略.
- 黄类化合物,如黄素 (Lut),具有多样化的药理活动.
研究的目的:
- 为了研究黄素对硫酸 (DSS) 诱导的小鼠性结肠炎 (UC) 的治疗作用.
- 阐明内细胞网膜 (ER) 应激和亡在黄素的保护机制中的作用.
- 为了在体外探索黄素对细胞ER应激和亡的影响.
主要方法:
- 在小鼠中使用DSS诱导UC.
- 对UC模型小鼠进行黄素的施用.
- 评估临床大肠炎得分,炎症标志物,肠道屏障完整性和肠道微生物群.
- 在体外研究使用HT29细胞治疗尼卡米 (TM) 或thapsigargin (TG) 有或没有luteolin和SIRT1沉默.
主要成果:
- 素治疗显著缓解了UC症状,包括减少炎症,改善肠道屏障功能和正常化肠道微生物群.
- 在结肠病小鼠中,素抑制了ER压力和亡.
- 在体外,黄素抑制了TM/TG诱导的ER压力和HT29细胞的亡,这种影响取决于SIRT1.
结论:
- 卢泰林通过减轻炎症和ER压力,证明了性结肠炎的显著治疗潜力.
- 这些发现支持氨酸作为预防和治疗人类炎症性疾病的有希望的药物.
- SIRT1参与调解黄素对ER压力和亡的保护作用.
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