Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Bone Remodeling01:40

Bone Remodeling

38.1K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.1K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

2.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Functionalizing biomaterials for osseointegration - microRNAs at the crossroads of bone formation and immune modulation.

Bone & joint research·2026
Same author

Combined analysis of host immune response, biofilm genes, and 16S rRNA detection in fracture-related infection: an observational cohort study.

Journal of bone and joint infection·2026
Same author

Pediatric papillary thyroid carcinoma: postoperative management and 14-year experience with radioiodine therapy at a Portuguese oncology centre.

European journal of pediatrics·2026
Same author

Biomimetic 3D-printed gyroid scaffolds with versatile bioactive coatings for complex craniomaxillofacial bone regeneration.

Biomedical materials (Bristol, England)·2026
Same author

Clinical significance of residual yellow-brown enamel opacities in severe molar incisor hypomineralisation: a cross-sectional study.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2026
Same author

<i>Echinococcus granulosus</i> antigen B acts as an LPS-scavenging lipoprotein <i>in vitro,</i> preventing TLR4-mediated activation of dendritic cells.

Infection and immunity·2025

相关实验视频

Updated: May 17, 2025

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
08:28

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling

Published on: May 21, 2020

6.6K

开发一个模仿骨的微环境:用于研究骨重塑的表面涂层方法in vitro

A Sieberath1,2,3, D Eglin4, C M Sprecher2

  • 1Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.

ACS biomaterials science & engineering
|April 10, 2025
PubMed
概括

研究人员开发了一种用于细胞培养板的新型涂层,以模仿骨环境. 这种新的检测方法可以同时测量骨形成和再吸收,有助于骨重塑研究.

关键词:
骨头改造 骨头改造 骨头改造共同培养是一种共同文化.在体外 (in vitro) 的情况下.骨质母细胞的骨质细胞.骨质结晶体的骨质细胞.

更多相关视频

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry
08:24

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry

Published on: March 14, 2020

6.7K
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.7K

相关实验视频

Last Updated: May 17, 2025

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
08:28

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling

Published on: May 21, 2020

6.6K
Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry
08:24

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry

Published on: March 14, 2020

6.7K
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.7K

科学领域:

  • 生物材料科学 生物材料科学
  • 细胞生物学 细胞生物学
  • 整形外科 整形外科 整形外科

背景情况:

  • 在体外研究骨形成和再吸收需要仿生微环境.
  • 现有的细胞培养基质缺乏必要的复杂性,无法准确地模拟骨重塑.

研究的目的:

  • 开发一种涂层技术,在细胞培养塑料 (CCP) 多孔板上创建类似骨的微环境.
  • 建立一种测试方法,在培养模型中同时测量细胞矿物质形成和再吸收.

主要方法:

  • 用模拟体液 (SBF) 补充了I型原蛋白,将I型原蛋白和碳酸性无酸的复合矩阵沉积在CCP上.
  • 使用qPCR和光显微镜评估了骨质分化,细胞附着和增殖.
  • 在涂层基板上评估了骨质细胞分化和再吸收活性.

主要成果:

  • 这种涂层成功地促进了骨质的分化,附着和人类骨髓衍生的间酶体干细胞的增殖.
  • 人类骨髓衍生单核细胞分化成功能性骨质细胞,这些骨质细胞重新吸收了被涂层的基质.
  • 建立了一个体外共培系统,可以实时监测矿物质的形成和再吸收.

结论:

  • 开发的涂层提供了一个生理学上相关的体外模型,用于研究骨重塑.
  • 这种检测有助于选治疗性化合物,并识别影响骨重塑的因素.
  • 该技术通过提供受控实验系统来增强骨健康的翻译研究.