患有代谢功能障碍与肝脏疾病相关的儿童的α-Fetoprotein水平升高
Jamie Klein1,2, Ana Catalina Arce-Clachar1,2,3, Kristin Bramlage1,3
1Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Childhood obesity (Print)
|April 10, 2025
概括
在儿科代谢功能障碍相关的脂肪性肝病 (MASLD) 中,晚期纤维化与阿尔法-胎蛋白 (AFP) 的升高没有相关性. 在一些患有MASLD的儿童中发生了AFP升高,但与恶性瘤无关.
科学领域:
- 儿科肝病学 儿科肝病学
- 胃肠病学 胃肠病学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 可以导致严重的肝病,如肝细胞癌 (HCC).
- 升高的α-fetoprotein (AFP) 是一个经常与肝病进展和HCC相关的标志物.
- 在儿科MASLD中AFP的作用,特别是纤维化严重程度,需要进一步研究.
研究的目的:
- 为了确定患有先进的MASLD相关纤维化 (桥梁纤维化或肝硬化) 的儿童中AFP升高的患病率.
- 评估儿科MASLD和AFP升高之间的关联,不论纤维化阶段.
主要方法:
- 在2000-2024年间对患有MASLD的儿科患者 (6-18岁) 进行了回顾性队列研究.
- 数据收集包括人口统计,人体测量,血液检查,肝脏活检结果和成像.
- 用描述性统计数据来分析数据.
主要成果:
- 在483名儿科MASLD患者中,有161人做了肝活检,22人显示有晚期纤维化.
- 没有任何晚期纤维化患者表现出高AFP水平.
- 整个MASLD队列中的9名患者有升高的AFP,没有人患有HCC或其他瘤.
结论:
- 儿科MASLD的晚期纤维化与升高的AFP水平无关.
- 虽然在儿科MASLD中可以出现AFP升高,但它们似乎与该队列中的恶性瘤无关.
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