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超声响应纳米粒子用于脑瘤的成像和治疗

Zhiguang Chen¹, Liang Sang¹, Zhai Qixi¹

¹Department of Ultrasound, The First Hospital of China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, China.

Materials today. Bio

|April 10, 2025

概括

带有微泡的聚焦超声波打开了血脑屏障,用于针对性脑瘤治疗. 这种方法提高了药物输送,并使得像免疫疗法这样的精确疗法能够获得更好的患者结果.

科学领域:

神经瘤学神经瘤学
生物医学工程生物医学工程
纳米技术纳米技术

背景情况:

中枢神经系统 (CNS) 癌症,如质母细胞瘤 (GBM),尽管采用标准治疗,但预后不佳.
血脑屏障 (BBB) 限制了药物输送,阻碍了有效的脑瘤治疗.
使用微气泡 (MB) 的聚焦超声波 (FUS) 提供了一种临时打开BBB的方法.

研究的目的:

审查使用FUS和超声响应纳米颗粒的脑瘤的精确传递和个性化治疗策略.
突出超声波介导BBB打开及其治疗应用的进步.
探索压电催化免疫疗法和临床翻译的潜力.

主要方法:

对聚焦超声波 (FUS) 和微气泡 (MBs) 进行BBB打开的文献综述.
通过FUS/MBs进行BBB调节的机制的讨论 (腔化,紧密结合,囊泡传输).
对超声响应纳米粒子进行分析,用于增强放射治疗,基因输送,免疫治疗和声动疗 (SDT).

主要成果:

FUS/MBs有效地和暂时地打开BBB,改善药物透.
超声响应纳米颗粒在各种脑瘤治疗模式中表现有前途.
压电催化免疫疗法是加强免疫反应的重点领域之一.

结论:

与MB和超声响应纳米颗粒相结合的FUS可为脑瘤提供精确的治疗.
通过调节超声波参数和免疫微环境,可以制定个性化的治疗策略.
这些先进治疗脑瘤的临床转化存在显著的潜力.

关键词:

大脑瘤是什么?质母细胞瘤 (glioblastoma) 是一个微气泡是一种微气泡.纳米颗粒纳米颗粒声动力学疗法声动力学疗法超声波超声波是指超声波的使用.

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Brain Imaging

Brain Imaging

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These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).