轮班工作与发作性易怒肠综合征的关联:一个基于大量人口的前性队列研究
Yang Zhong1,2, Hao Bai2, Yuan Zhang2
1Department of Epidemiology and Health Statistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Frontiers in public health
|April 10, 2025
概括
轮班工作增加了刺激性肠综合征 (IBS) 的风险. 睡眠不足和失眠可能会加剧这种风险,焦虑,抑郁和睡眠质量作为调解因素.
科学领域:
- 流行病学 流行病学
- 胃肠病学 胃肠病学
- 职业健康 职业健康 职业健康
背景情况:
- 刺激性肠综合征 (IBS) 是一种常见的胃肠疾病.
- 有限的流行病学数据存在于轮班工作和IBS风险之间的关联.
- 了解影响IBS的职业因素对于公共健康至关重要.
研究的目的:
- 调查轮班工作与发展IBS的风险之间的联系.
- 探索这种关系中的潜在调解因素,如睡眠质量和心理健康.
主要方法:
- 利用了来自268,290名参与者的英国生物库数据.
- 雇员考克斯比例危险模型来评估轮班工作和IBS发生率.
- 进行调解分析以确定导致因素.
主要成果:
- 常常/通常轮班工作与IBS风险显著增加有关 (HR:1.12).
- 与睡眠不足或失眠相结合的轮班工作进一步增加了IBS风险 (HR:分别为1.54和1.65).
- 睡眠质量和焦虑/抑郁症部分介导了轮班工作与IBS的联系.
结论:
- 轮班工作是发生IBS事件的重要风险因素.
- 焦虑,抑郁和睡眠质量差部分介于这种关联.
- 睡眠不足和失眠会加剧轮班工人患IBS的风险.
相关概念视频
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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
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