与使用局部绿眼病药物相关的皮肤皮肤下色素化
Sam Karimaghaei1, Jeff Yee1, Abdelrahman M Elhusseiny1
1Harvey and Bernice Jones Eye Institute, Department of Ophthalmology, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Department of Ophthalmology, John L. McClellan Memorial Veteran's Hospital, Little Rock, Arkansas.
Digital journal of ophthalmology : DJO
|April 10, 2025
概括
长期使用青光眼的眼滴可能会导致眼睛周围皮肤变白. 这种罕见的副作用,周期性下色素化,很可能与拉坦诺普罗斯特使用有关.
科学领域:
- 眼科医生 眼科 眼科
- 皮肤病学 皮肤病学
背景情况:
- 局部药物,如前列腺素类似物,β-阻断剂,α-2激动剂和碳酸酶抑制剂是眼睛高血压和玻璃眼的标准治疗方法.
- 这些药物可能会引起各种不良反应,影响患者的药物坚持和生活质量.
研究的目的:
- 报告一种罕见的双边周期性低颜色化病例.
- 为了研究长期局部格劳科马药物使用和皮肤皮肤色素脱落的矛盾之间的潜在联系.
主要方法:
- 一个72岁的女性患者的病例报告.
- 关于药物的副作用的眼科文献的综述.
主要成果:
- 在长期使用拉坦诺普罗斯特,蒂莫洛尔和布林佐胺/布里莫尼丁后,该患者出现了双边周期性低颜色.
- 众所周知,前列腺素类似物会导致多发色素,但很少报告矛盾的低发色素.
- 蒂莫洛尔和布林佐胺/布里莫尼丁没有与皮肤色素变化有记录的关联.
结论:
- 观察到的低颜色可能是拉坦诺普罗斯特的罕见,矛盾的副作用.
- 这个案例为眼科中药物诱导的皮肤脱色素的有限文献做出了贡献.
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