骨矿物质密度和中风之间的关联:一个元分析.
1Department of Neurology, The Second Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei Province, China.
Frontiers in neurology
|April 10, 2025
概括
较低的骨矿物质密度 (BMD) 与较高的中风风险有关. 这种关联在女性中尤为显著,表明骨健康和脑血管事件之间存在潜在联系.
科学领域:
- 骨生物学和新陈代谢
- 神经学和脑血管疾病.
- 流行病学和公共卫生.
背景情况:
- 骨矿物质密度 (BMD) 和中风风险之间的关系尚未完全理解,现有研究显示了不一致的发现.
- 了解这种关联对于识别患中风风险较高的个体和制定预防策略至关重要.
研究的目的:
- 系统地评估骨矿物质密度 (BMD) 降低与中风风险之间的关联.
- 为了确定低的BMD是否是不同人群中发生中风的重要预测因素.
主要方法:
- 在Medline,Embase和Cochrane系统评论数据库中进行了全面的系统文献搜索,截至2025年1月.
- 用随机效应模型对13项队列研究进行了聚合分析,其中包括146,758名参与者,以评估与减少骨质量相关的中风风险.
主要成果:
- 骨硬度减少1个标准偏差 (SD) 与中风风险增加显著相关 (RR,1.24;95% CI,1.09-1.40).
- 亚组分析显示,这种关联在女性个体 (RR,1.28;95% CI,1.09-1.51) 与男性个体 (RR,1.04;95% CI,0.99-1.10) 相比更为明显.
- 患有骨质疏松症或骨质疏松症的个人表现出发生性中风的风险明显更高 (RR, 1.59; 95% CI, 1.22-2.08).
结论:
- 骨矿物质密度 (BMD) 降低是中风的重要危险因素.
- 与男性同行相比,女性 BMD 较低的人面临更高的中风风险.
- 这些发现强调了在评估中风风险时考虑骨健康的重要性,特别是在女性中.
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