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在长期COVID患者的老年人中,功能网络内脑血管反应的变化

Jessica M Pommy¹, Alexander Cohen², Amarpreet Mahil²

¹Division of Neuropsychology, Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, United States.

Frontiers in neurology

|April 10, 2025

概括

长期COVID患者的老年人表现出大脑血管活性 (CVR) 的改变,影响认知功能. 这些神经血管变化与长期COVID患者的认知症状和性能缺陷有关.

科学领域:

神经科学是一个神经科学.
老年学是指老年学的学科.
传染性疾病传染性疾病

背景情况:

长期COVID经常与认知症状有关,特别是在老年人中,他们也面临更高的认知衰退风险.
神经血管机制,特别是脑血管反应 (CVR),与年龄相关的认知衰退有关,但在长期COVID中仍未被探索.

研究的目的:

为了研究长期COVID和没有长期COVID的老年人之间的CVR差异.
探索CVR,主观认知投诉和长期COVID中的客观神经心理表现之间的关联.

主要方法:

长期COVID的31名老年人的CVR与没有长期COVID的31名认知正常的老年人的CVR进行了比较.
采用了特定学科的方法,即分布校正的Z分数 (DisCo-Z).
检查了CVR,主观认知症状和神经心理测试结果之间的相关性.

主要成果:

长期COVID组在与注意力和执行功能相关的大脑区域中表现出更高的极端CVR集群的发病率.
极端积极的CVR集群与主观认知症状的增加有关.
极端积极的CVR集群与神经心理学表现有负相关性.

结论:

这项研究提供了新的证据,将神经血管变化 (CVR) 与长期COVID患者的老年人认知障碍联系起来.
这些发现突出了神经血管功能障碍在长期COVID的认知后果中的潜在作用,特别适用于老年人群.

关键词:

衰老的衰老衰老的衰老大脑网络大脑网络大脑血管反应活性大脑血管反应认知认知认知功能性核磁共振成像 (MRI) 功能性核磁共振成像一个个个个个个个个个个个个个个.长时间的COVID.这是神经血管神经系统.

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