研究在深层溶解剂中可纳的药物行为:热力学特性,溶解度测量和光谱学
Hadi Azad1, Hemayat Shekaari1, Fariba Ghaffari1
1Department of Physical Chemistry, University of Tabriz Tabriz Iran hemayatt@yahoo.com +98-4133340191 +98-4133393094.
RSC advances
|April 10, 2025
概括
这项研究研究了可纳 (FCZ) 与新型深度浸泡溶剂 (DES) 的相互作用. 胆化物-酸DES显示最强的相互作用,增强FCZ溶解性,并提供了对抗真菌药物配方的见解.
科学领域:
- 物理化学 物理化学
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
背景情况:
- 可纳 (FCZ) 是一种重要的抗真菌剂.
- 深度浸泡溶剂 (DES) 为药物配方提供独特的特性.
- 了解药物溶剂相互作用是优化药物输送的关键.
研究的目的:
- 为了研究流可纳 (FCZ) 和合成的基于胆化物的深溶解剂 (DESs) 之间的相互作用.
- 评估DESs对可纳溶解度和热力学特性的影响.
- 探索DESs作为抗真菌药物输送的新媒体的潜力.
主要方法:
- 合成五种基于胆化的DES,使用不同的键供体 (氧酸,马龙酸,乙烯糖醇,甘油,尿素).
- 光光谱学研究FCZ-DES相互作用在298.15K.
- 在温度范围 (298.15313.15 K) 中测量了FCZ在DES-水混合物中的可溶性.
- 应用热力学模型 (e-NRTL,威尔逊) 和导体样选模型 (COSMO) 的计算.
主要成果:
- 光谱学证实了FCZ和DES之间强烈的相互作用,光火证实了这一点.
- 胆化物-氧酸DES表现出与FCZ最显著的相互作用.
- 在DES-水混合物中,DES度较高时,FCZ溶解度增加.
- 热力学分析表明,FCZ的内热溶解过程.
结论:
- 深度浸泡溶剂,特别是胆化-酸,显示出增强可溶性和相互作用的显著潜力.
- 这些发现提供了对DESs中FCZ行为的分子间相互作用的宝贵见解.
- 这项研究支持使用DES技术开发抗真菌药物的先进配方.
相关概念视频
01:20Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
158
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
158
01:26Variables Affecting Phosphorescence and Fluorescence
396
Fluorescence and phosphorescence are essential phenomena in fields like analytical chemistry, biological imaging, and materials science, where they detect molecular properties and visualize cellular structures. Understanding the variables that influence these luminescent behaviors is crucial for maximizing accuracy and efficiency in their applications. These variables can broadly be grouped into chemical structure, solvent properties, and external conditions, each playing a distinct role in...
396
01:27Factors Influencing Drug Absorption: Drug Dissolution
378
The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
378