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是否可以使用来自异常受精的胚胎细胞的胚胎囊? 一个系统的审查和元分析
Yiqing Wu1, Jinglei Xue1, Mixue Tu1
1Women's Reproductive Health Research Key Laboratory of Zhejiang Province and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China.
概括
单核 (1PN) 和非核 (0PN) 囊可能是可行的生育选择. 虽然通常与成功率低于两核 (2PN) 芽细胞相比,但1PN和0PN芽细胞在特定的辅助生殖技术中显示出相似的活产率.
科学领域:
- 生殖医学 生殖医学
- 胚胎学 胚胎学
- 在体外受精过程中受精.
背景情况:
- 目前的指导方针不鼓励用于临床目的的单核 (1PN) 或非核 (0PN) 胚胎.
- 新出现的证据表明,1PN和0PN胞胎可以导致成功的怀孕和健康的分娩.
研究的目的:
- 为了研究和比较与转移1PN和0PN胚胎细胞结核相比标准的两个前核 (2PN) 胚胎细胞结核相关的怀孕结果.
- 在不同辅助生殖技术 (ART) 受精方法中评估1PN和0PN胚胎囊的疗效.
主要方法:
- 我们对PubMed,EMBASE,Web of Science和Cochrane数据库进行了系统的文献搜索.
- 进行了对16项研究 (57,835个周期) 的元分析,比较了1PN,0PN和2PN芽细胞移植.
- 结果包括临床怀孕率,流产率和活产率,使用随机效应模型分析并按受精类型分层 (IVF/ICSI).
主要成果:
- 1PN和0PN胚囊与2PN胚囊相比,与显著较低的临床怀孕和活产率有关.
- 在细胞内注射精子 (ICSI) 循环中,在1PN和2PN胚芽细胞之间没有观察到活产率的显著差异.
- 同样,在体外受精 (IVF) 周期中,在0PN和2PN胚芽细胞之间没有发现活产率的显著差异.
结论:
- 使用1PN和0PN胚胎囊需要仔细考虑,特别是随着非侵入性受精评估的进展.
- 在ICSI周期中的1PN胚胎囊和IVF周期中的0PN胚胎囊代表了异常受精患者的潜在可行的生育选择.
- 这些发现表明,特定类型的异常受精可能不会在定制ART方法中排除成功的妊娠结果.
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