患有慢性乙型肝炎的患者在核胺模拟疗法下使用Omicron BA.5感染:中国南方的一项回顾性研究
Peipei Wang1,2,3, Junjian Chen3,4, Dabiao Chen1,2,3
1Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Liver research (Beijing, China)
|April 10, 2025
概括
患有慢性乙型肝炎 (CHB) 的患者在感染Omicron BA.5后经历了较轻的COVID-19症状. 在CHB患者中,诺福维尔 (TFV) 治疗与感染后较高的SARS-CoV-2抗体水平相关.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 对于Omicron BA.5感染后的慢性乙型肝炎 (CHB) 患者,临床数据有限.
- 了解感染Omicron BA.5的CHB患者的临床特征对于患者护理至关重要.
研究的目的:
- 评估Omicron BA.5感染后CHB患者的临床特征.
- 为了比较Omicron BA.5感染后的CHB患者和健康个体之间的临床结果.
主要方法:
- 553名CHB患者和485名健康个体的回顾性研究 (2023年1月至3月).
- 测量了COVID-19症状,SARS-CoV-2抗体水平,疫苗接种状态,肝功能和HBV标志物.
- 将CHB患者和对照组之间的结果进行比较,并分析了核胺类比疗法 (ETV与TFV) 的效果.
主要成果:
- 与健康个体相比,CHB患者报告发烧的流行率较低,持续时间较短.
- 血球蛋白 (GLB) 和乙肝包膜抗体水平在感染后的CHB患者中增加.
- 服用特诺福维尔 (TFV) 的患者的SARS-CoV-2抗体水平明显高于服用恩特卡维尔 (ETV) 的患者.
结论:
- 在CHB患者中,Omicron BA.5感染并没有显著加剧COVID-19症状.
- 观察到HBV的重新激活,但肝功能基本保持稳定.
- 在CHB患者中,TFV治疗可能会增强SARS-CoV-2抗体反应;需要进一步研究.
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