相关实验视频

Updated: May 15, 2025

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

Published on: April 18, 2019

暴露于per-和多基物质与功能之间的关联:一项人口研究

Xue Zhang¹, Yongping Cao², Xiaona Yang³

¹School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.

Frontiers in medicine

|April 10, 2025

概括

暴露于per-和多醇基物质 (PFAS) 与降低功能有关. 这项研究发现,各种PFAS化学物质与损伤标志物之间存在显著的关联,突出了潜在的健康风险.

科学领域:

环境健康科学环境健康科学
毒理学毒理学毒理学
流行病学流行病学

背景情况:

和多醇基物质 (PFAS) 是广泛使用的合成化学物质,对功能产生不确定的影响.
现有研究提出了关于PFAS暴露和脏健康标志物之间的关系的相互矛盾的证据.

研究的目的:

在大量成年人群中调查暴露于特定PFAS和功能关键指标之间的关联.
探索PFAS对脏健康的潜在非线性关系和混合作用.

主要方法:

利用了2005-2012年国家健康和营养检查调查 (NHANES) 中5947名成年人的数据.
采用多变量线性回归,受限立方线,加权量子和 (WQS) 和量子g计算 (Q-gcomp) 模型进行关联和混合分析.
进行子组分析以确定潜在的相互作用效应.

主要成果:

一些PFAS,包括PFOA,PFOS和PFHxS,与估计的淋巴膜过率 (eGFR) 有负相关性.
观察到PFAS和尿氨酸 (UCR),尿蛋白 (UAL) 和尿蛋白/尿蛋白比率 (UACR) 之间存在关联,具有混合的正负关系.
检测到所有功能指标的非线性关系,混合的PFAS暴露显示出与eGFR,UAL和UACR的负相关性.

结论:

这项研究表明,暴露于各种PFAS和多种功能指标之间存在显著的关联.
研究结果表明,暴露于PFAS可能会导致功能障碍,为环境健康风险提供了重要的流行病学视角.
需要进一步的研究来阐明PFAS对脏健康的机制和长期影响.

关键词:

国家健康和营养检查调查调查美国GFRGFR 功能功能功能混合暴露的混合暴露.聚甲基化学品的多化物化学品.

更多相关视频

Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique

Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique

Published on: September 28, 2022

Highly Sensitive Measurement of Glomerular Permeability in Mice with Fluorescein Isothiocyanate-polysucrose 70

Highly Sensitive Measurement of Glomerular Permeability in Mice with Fluorescein Isothiocyanate-polysucrose 70

Published on: August 9, 2019

相关概念视频

Factors Affecting Renal Clearance: Renal Impairment

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...

Kidney Structure

Kidney Structure

The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.