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Updated: May 15, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

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自组装的PROTACs使活细胞中的糖蛋白降解成为可能

Haoyu Chen1, Liu Zang1, Pavel Kielkowski1

  • 1Department of Chemistry, LMU Munich Würmtalstr. 201 81375 Munich Germany pavel.kielkowski@cup.lmu.de.

Chemical science
|April 10, 2025
PubMed
概括

这项研究介绍了GlyTAC,一种新型的向化母的蛋白质分解 (PROTAC) 策略,可降解癌细胞糖蛋白. GLYTAC利用改性糖来选择性地消除标蛋白,提供了一个潜在的新型癌症治疗方法.

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Delivery of Proteins, Peptides or Cell-impermeable Small Molecules into Live Cells by Incubation with the Endosomolytic Reagent dfTAT10:30

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