心脏代谢指数与高尿血的非线性关联:来自NHANES 1999-2018研究的见解
Xumei Yang1,2, Yulan Luo1,2, Wei Lai1
1Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
Frontiers in endocrinology
|April 10, 2025
概括
较高的心脏代谢指数 (CMI) 与增加的高尿路血症风险有关. 这种关联是非线性的,在较低的CMI水平下,风险加速,突出了早期干预的必要性.
科学领域:
- 代谢健康 代谢健康
- 心血管流行病学心血管流行病学
背景情况:
- 高尿路血是痛风和心血管疾病的危险因素.
- 它与各种代谢障碍有关.
研究的目的:
- 为了研究心脏代谢指数 (CMI) 和高尿血症之间的关联.
- 探索潜在的非线性关系,并确定转折点.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 1999-2018年数据 (n=23,212).
- 员工调查加权后勤回归和一般化添加模型.
- 在人口和健康子组进行了分层分析.
主要成果:
- 在较高的CMI和增加的高尿路血症之间发现了显著的关联.
- 确定了一种非线性关系,在较低的CMI水平下,风险加速.
- 这种模式在所有分析的子组中都是一致的.
结论:
- 较高的CMI显著预测不同人群中的高尿路血症.
- 这种明显的非线性关联强调了早期干预的重要性.
- 个性化风险评估和有针对性的策略至关重要.
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