介质素-39在多流中的表达及其对结核性多病的诊断价值
Xuxiang Song1,2, Qipan Zhang3, Tiantian Cen1,3
1Health Science Center, Ningbo University, Ningbo, People's Republic of China.
Journal of inflammation research
|April 10, 2025
概括
介素-39 (IL-39) 对结核性多炎 (TPE) 具有很高的诊断价值,其表现优于其他多溢液类型. 将IL-39与其他生物标志物的结合显著改善了TPE诊断,并揭示了它在结核病炎症中的作用.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 生物标志物发现发现
背景情况:
- 胸腔溢出 (PE) 诊断可能具有挑战性,特别是区分结核性胸腔溢出 (TPE) 与其他原因,如恶性胸腔溢出 (MPE) 和肺周溢出 (UPPE).
- 介乐-39 (IL-39) 是一种涉及炎症过程的细胞因子,但其在PE,特别是TPE的诊断效用需要进一步研究.
研究的目的:
- 为了评估多种类型的多流液 (PE) 中的干白素-39 (IL-39) 水平.
- 评估IL-39对于结核性多症 (TPE) 的诊断和差异诊断价值.
- 探索IL-39与已知结核病生物标志物的相关性及其在炎症反应中的作用.
主要方法:
- 使用酶相关免疫吸收试验 (ELISA) 在液 (PF) 中量化IL-39,干扰素- (IFN-γ) 和瘤亡因子-α (TNF-α).
- 通过色度测量方法测量腺氨酸脱氨酶 (ADA) 活性.
- 使用接收器操作特征 (ROC) 曲线分析诊断性能,包括曲线下的面积 (AUC),切线值,灵敏度和特异性.
主要成果:
- 在TPE中,IL-39水平显著增加,而在转化性,MPE和UPPE组中,IL-39水平明显增加.
- IL-39在TPE的诊断准确度很高,AUC在不同的比较中从0.885到0.944不等.
- 结合IL-39与IFN-γ,TNF-α和ADA的多变量诊断模型显著提高了TPE的诊断性能.
结论:
- IL-39 作为一个有价值的生物标志物用于诊断和差异诊断的TPE.
- 与IFN-γ,TNF-α和ADA等其他生物标志物的IL-39联合检测可以提高TPE的诊断灵敏度和特异性.
- IL-39与其他结核病生物标志物之间的正相关性表明,它在结核病感染期间参与了炎症反应.
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