相关实验视频

Updated: May 15, 2025

Neuropharmacological Manipulation of Restrained and Free-flying Honey Bees, Apis mellifera
11:08

Neuropharmacological Manipulation of Restrained and Free-flying Honey Bees, Apis mellifera

Published on: November 26, 2016

9.8K

基于全米缩放和药理动力学建模方法,预测新组合蜂毒的首次人体剂量

Soon Uk Chae1, Jee Sun Min1, Seong Jun Jo1,2

  • 1College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon 14662, Korea.

Translational and clinical pharmacology
|April 10, 2025
PubMed
概括

一种新的蜜蜂毒成分 (NCBV) 显示出对阿尔茨海默氏症的治疗有希望. 药物动力学建模预测了1.3毫克的安全首次人体剂量,用于NCBV,这是一种蜂毒酸酶A2 (bvPLA2) 强化的治疗方法.

关键词:
所有度尺度缩放 (Allometric Scaling) 是一种方法.蜜蜂毒酸酶A2是什么FIH 剂量 时间非线性混合效果建模模型药理动力学 药理动力学

更多相关视频

Preparation of Virus-Enriched Inoculum for Oral Infection of Honey Bees Apis mellifera06:41

Preparation of Virus-Enriched Inoculum for Oral Infection of Honey Bees Apis mellifera

Published on: August 26, 2020

2.8K
Empirical, Metagenomic, and Computational Techniques Illuminate the Mechanisms by which Fungicides Compromise Bee Health08:36

Empirical, Metagenomic, and Computational Techniques Illuminate the Mechanisms by which Fungicides Compromise Bee Health

Published on: October 9, 2017

9.6K

相关概念视频

Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
26
Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
202
Pharmacokinetic Models: Overview01:20

Pharmacokinetic Models: Overview

Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal...
509
Dose-Response Relationship: Overview01:03

Dose-Response Relationship: Overview

Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
2.8K
One-Compartment Open Model for Extravascular Administration: First-Order Absorption Model01:15

One-Compartment Open Model for Extravascular Administration: First-Order Absorption Model

The first-order absorption model for extravascular administration describes the rate at which a drug is absorbed and eliminated, following the principles of first-order kinetics. This model is vital as it provides a mathematical representation of drug behavior within the body. It also allows for the prediction and interpretation of drug absorption and elimination based on the rate of change in drug concentration over time. This model can be visualized as a plasma concentration-time profile...
173