基于机器学习的探索多种矿物质摄入量和甲状腺功能障碍之间的关联:来自国家健康和营养检查调查的数据
Shaojie Liu1,2, Weibin Huang3, Yaming Lin1
1The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Frontiers in nutrition
|April 10, 2025
概括
矿物质摄入量显著影响甲状腺功能障碍 (TD). 较高的,和摄入量与较低的甲状腺功能障碍风险相关,而摄入量增加了风险. 均衡的矿物质消费是甲状腺健康的关键.
科学领域:
- 营养科学 营养科学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 甲状腺功能障碍 (TD) 的患病率在全球范围内正在上升.
- 矿物质摄入量和TD之间的关系尚不清楚,可能是由于协同效应.
- 了解这些关联对于预防策略至关重要.
研究的目的:
- 研究多种矿物质摄入对甲状腺功能障碍的个人和联合影响.
- 探索饮食中矿物质消费与甲状腺功能过高和甲状腺功能低下之间的关联.
- 为了确定影响甲状腺健康的关键矿物质.
主要方法:
- 利用了2001-2002年和2007-2012年国家健康和营养检查调查 (NHANES) 的数据.
- 收集了多种矿物质的饮食摄入数据,并测量了甲状腺功能标志物 (自由T3,自由T4,TSH).
- 在7779名参与者中使用加权多变量逻辑回归和机器学习模型 (WQS,qg-comp,BKMR).
主要成果:
- 更高的,和摄入量与较低的甲状腺功能障碍 (ORs <0.591) 患病率有关.
- 增加摄入量与较高的甲状腺功能障碍 (OR = 1.262) 患病率有关.
- 机器学习模型表明,九种矿物质和TD之间存在共同的负相关性,其中突出的是,,铜和.
结论:
- 均衡摄入多种矿物质对于预防和管理甲状腺功能障碍至关重要.
- ,,和等特定矿物质与甲状腺健康有明显的关联.
- 对矿物质协同作用的进一步研究是全面的TD管理的必要条件.
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